By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme
Traditionally, rules governing chemical use have usually interested by everyday chemical substances and acute human future health results of publicity to them, in addition to their capability to reason melanoma and different adversarial wellbeing and fitness results. As medical wisdom has improved there was an elevated information of the mechanisms wherein chemical compounds may perhaps exert damaging results on human wellbeing and fitness, in addition to their results on other species and ecosystems. identity of high-priority chemical substances and different chemical compounds of outrage has brought on progressively more country and native governments, in addition to significant businesses, to take steps past latest harmful chemical federal laws. curiosity in methods and rules that make sure that any new ingredients substituted for chemical compounds of outrage are assessed as conscientiously and carefully as attainable has additionally burgeoned. The overarching aim of those techniques is to prevent regrettable substitutions, which take place while a poisonous chemical is changed by means of one other chemical that later proved incorrect as a result of endurance, bioaccumulation, toxicity, or different matters. Chemical substitute tests are instruments designed to facilitate attention of those components to help stakeholders in opting for chemical compounds which could have the best chance of damage to human and ecological overall healthiness, and to supply assistance on how the may perhaps strengthen and undertake more secure choices. A Framework to steer collection of Chemical choices develops and demonstrates a choice framework for comparing probably more secure alternative chemical compounds as essentially made up our minds by way of human overall healthiness and ecological hazards. This new framework is trained via past efforts via regulatory companies, educational associations, and others to enhance replacement evaluate frameworks that may be operationalized. as well as danger tests, the framework contains steps for life-cycle pondering - which considers attainable affects of a chemical in any respect phases together with construction, use, and disposal - in addition to steps for functionality and fiscal checks. The record additionally highlights how sleek info resources resembling computational modeling can complement conventional toxicology facts within the evaluate method. This new framework permits the evaluate of the entire variety of advantages and shortcomings of substitutes, and exam of tradeoffs among those dangers and elements corresponding to product performance, product efficacy, approach defense, and source use. via case experiences, this file demonstrates how varied clients in contrasting choice contexts with various priorities can follow the framework. This record might be an important source to the chemical undefined, environmentalists, ecologists, and kingdom and native governments. Read more...
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Additional resources for A framework to guide selection of chemical alternatives
Throughout the process, several key decisions, listed below, were made, which also helped determine the framework's structure. The framework is to be used by a multidisciplinary team of individuals with training and expertise in toxicology (human health and ecotoxicology), exposure assessment, chemistry, and life cycle assessment. Additional expertise in engineering, epidemiology, social sciences, economics, and cost analysis may also be required. Assessors without such expertise, such as small- and medium-sized firms, may need user-friendly assessment tools or technical support to carry out parts of the committee’s framework.
The IC2 Alternatives Assessment Guide focuses on “reducing risk by reducing hazard” (OECD 2013a). The guidance includes a set of principles for alternatives assessments (OECD 2013a), and three decision-making framework options: sequential, simultaneous, and hybrid (IC2 2013). IC2’s frameworks stand out for including flexibility as a principle and mentioning the role of green chemistry as an approach for designing safer chemicals (OECD 2013a). The IC2 framework includes seven modules, each evaluating a different consideration for assessing potential alternatives, which users can choose among to conduct an assessment.
Inputs: List of alternatives from Step 7. STEP 7: INTEGRATION OF INFORMATION TO IDENTIFY SAFER ALTERNATIVES Goals: Identify safer alternatives on the basis of information compiled in previous steps. If no alternatives are considered safer than the chemical of concern, initiate research to develop new alternatives or improve existing alternatives. 3. Outputs: List of safer alternatives and supporting documentation for each, including actions needed to offset trade-offs or detect unintended consequences.