Download A framework to guide selection of chemical alternatives by National Research Council, Division on Earth and Life PDF

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme

Traditionally, rules governing chemical use have usually interested by everyday chemical substances and acute human future health results of publicity to them, in addition to their capability to reason melanoma and different adversarial wellbeing and fitness results. As medical wisdom has improved there was an elevated information of the mechanisms wherein chemical compounds may perhaps exert damaging results on human wellbeing and fitness, in addition to their results on other  Read more...

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Throughout the process, several key decisions, listed below, were made, which also helped determine the framework's structure.  The framework is to be used by a multidisciplinary team of individuals with training and expertise in toxicology (human health and ecotoxicology), exposure assessment, chemistry, and life cycle assessment. Additional expertise in engineering, epidemiology, social sciences, economics, and cost analysis may also be required. Assessors without such expertise, such as small- and medium-sized firms, may need user-friendly assessment tools or technical support to carry out parts of the committee’s framework.

The IC2 Alternatives Assessment Guide focuses on “reducing risk by reducing hazard” (OECD 2013a). The guidance includes a set of principles for alternatives assessments (OECD 2013a), and three decision-making framework options: sequential, simultaneous, and hybrid (IC2 2013). IC2’s frameworks stand out for including flexibility as a principle and mentioning the role of green chemistry as an approach for designing safer chemicals (OECD 2013a). The IC2 framework includes seven modules, each evaluating a different consideration for assessing potential alternatives, which users can choose among to conduct an assessment.

Inputs: List of alternatives from Step 7. STEP 7: INTEGRATION OF INFORMATION TO IDENTIFY SAFER ALTERNATIVES Goals: Identify safer alternatives on the basis of information compiled in previous steps. If no alternatives are considered safer than the chemical of concern, initiate research to develop new alternatives or improve existing alternatives. 3. Outputs: List of safer alternatives and supporting documentation for each, including actions needed to offset trade-offs or detect unintended consequences.

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