Download Annual Reports in Medicinal Chemistry, 4 by C K Cain PDF

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P r o n e t h a l o l blocked t h e e f f e c t on the h e a r t b u t n o t t h a t on blood pressugg. Heart norepinephrine was reduced, b u t n o t that i n b r a i n . The blood pressure of r e n a l hypertensive ( b u t n o t normotensive) * ? a t s was reduced by 3,5-dihydroxy-4-methoxyNorepinephrine l e v e l s i n h e a r t and b r a i n were phenylalanine. reduced and 3,5 dihydroxy-4-methoxyphenethylamine was p r e s e n t ? ' Both e f f e c t s were prevented by t h e decarboxylase in- - 50 Sect.

79. J. D. S. , 160, 217( 1968). 80. J. C. A. Johnson and C. J. Pharmacol. , 2,295(1968). 81. M. Smith, E. H. K. Pharrnaco1. Therap,, *,468(1968). 82. P. Burn. , 34,251(1968). 83. H. , 18,919(1968). S e c t i o n I1 - Pharmacodynamic a g e n t s Barry M. Bloom, Chas. P f i z e r & Co. Groton, Conn. Editor: Chapter 5. , Inc. Antihypertensive Drugs F’ranklin M. Robinson Merck Sharp & Dohme Research Laboratories, West P o i n t , Pa. An unusually l a r g e p r o p o r t i o n of t h e r e s e a r c h r e p o r t e d during 1968 concerned mechanisms of a c t i o n of compounds prev i o u s l y r e p o r t e d t o be c l i n i c a l l y e f f e c t i v e .

H a l l and C. R. Stephen, B r i t . J. Anaesthesia 40, 511 (1968). 49. B. Dobkin, R. G. Heinrick, J. S. I s r a e l , A. A. Levy, 3. F. N e v i l l e and K. Ounkasem, Anesthesiology 29(2), 275 (1968). - . c. - Chapter 4. Analgesic Agents J .?. K. , a l t h o u g h c o n t i n u e d plrogress has ’neen m d e towards t h e e v e n t u a l i n t r o - hportant duc t i o n of ap. o r a l l y a c t i v e non-adAictive s t r o n g a n a l g e s i c . g t h e yharn:acological and c l i n i c a l e v a l u a t i o n of a n , d g e s i c s e s p e c i a l l y w i t h r e g a r d t o t h e assessment o f n a r c o t i c antap;onists.

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