By John J. Langone (Eds.)
The severely acclaimed laboratory average, Methods in Enzymology, is likely one of the so much hugely revered courses within the box of biochemistry. when you consider that 1955, every one quantity has been eagerly awaited, usually consulted, and praised via researchers and reviewers alike. The sequence includes a lot fabric nonetheless correct this present day - really an important e-book for researchers in all fields of existence sciences
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Extra info for Antibodies, Antigens, and Molecular Mimicry
Example text
A. 79, 4810 (1982). 126j. y . Couraud, E. Escher, D. Regoli, V. Imhoff, B. Rossignol, and P. PradeUes, J. Biol. Chem. 2611, 9461 (1985). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 25 immunizing rabbits with antisubstance P antibodies. These anti-idiotypic antibodies inhibited the spasmogenic action of substance P on the guinea pig ileum. They specifically enhanced phospholipid turnover in rat parotid gland cells, a physiological function mediated through an activation of substance P receptors, in a similar way to substance P.
Two of the immunized rabbits developed signs of muscular weakness resembling the symptoms of myasthenia gravis. These findings prompted the authors to propose that a similar mechanism may play a role in the etiology of at least some autoimmune disorders in which antibodies to various other receptors may be involved. Anti-idiotypic Antibodies to Substance P Receptors Polyclonal antibodies raised against substance P were characterized for their specificity toward substance P and about 30 substance P-related peptides.
128, 595 (1982). E. Trenkner and R. Riblet, J. Exp. Med. 142, 1121 (1975). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 13 T15 antibodies were able to induce in vitro an anti-PC plaque-forming cell (PFC) response in the absence of the antigen. McNamara et al. 28 have induced effective immunity and protection against a lethal dose of S. p n e u m o n i a e in mice using the monoclonal anti-idiotypic antibody 4C1 1. Interestingly, the monoclonal antibody in its unaltered form did not induce anti-streptococcal immunity nor any significant increase in the effective antibody idiotype.
