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2007). 40 Kulis and Esteller IV. DNA METHYLATION MARKERS Despite our constantly growing understanding of carcinogenesis, there is still an eager needs to design novel, powerful tools that can be applied as part of clinical practice. Tumor biomarkers are indispensable not only for early diagnosis of cancer but also for prognosis, prediction of therapeutic response, monitoring therapy, or assessment of risk of recurrence after curative surgery. Many different molecules, including nucleic acids, proteins, or even small metabolites, could be used as the indicators of tumorigenesis.

For diagnostic purposes, it would be sufficient to prove the correlation between DNA methylation pattern and tumor development. , 2005). Nevertheless, a significant association of Vimentin methylation with Dukes’ stage and preferences for developing 2. , 2009). DNA methylation markers are conjectured to play a role as predictive factors. They may be useful for determining not only the outcome of the disease but also the individual response to chemotherapy. Furthermore, monitoring DNA methylation profiles after treatment or curative surgery may yield evidence concerning the efficiency of applied therapy or detect disease recurrence.

These powerful tools are beginning to be applied to large population-based and case-control studies which offer some of the most exciting opportunities to study the contribution of epigenetic events to specific human cancers. Chapter 7, Vol. 71 (by Yasuhito Yuasa) discusses the application of epigenetics to molecular epidemiology, such as assessment of exposure to environmental epimutagens by epigenetic markers. It also covers different considerations relevant to molecular epidemiology studies, regarding the adoption of stringent criteria for the design, conduct, and evaluation of studies in which epigenetic markers are applied.

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Download AVO and Seismic Attributes: Principles and Applications - by Thapar M.R. PDF
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