Download Basic and Clinical Pharmacology 12/E by Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor PDF

By Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor

The latest, complete, and authoritative pharmacology textual content in health and wellbeing medicine

Enhanced through greater than 300 illustrations -- many in complete color

Organized to mirror the syllabi in lots of pharmacology classes and in built-in curricula, Basic & scientific Pharmacology, 12e covers the $64000 innovations scholars want to know concerning the technological know-how of pharmacology and its software to scientific perform. number of the subject material and order of its presentation are in response to the authors’ a long time adventure in instructing this fabric to millions of scientific, pharmacy, dental, podiatry, nursing, and different well-being technology students.

To be as clinically correct as attainable, the publication contains sections that in particular deal with the medical selection and use of gear in sufferers and the tracking in their results, and case stories that introduce medical difficulties in lots of chapters. offered in complete colour and more advantageous by means of greater than 300 illustrations, Basic & medical Pharmacology beneficial properties various precis tables and diagrams that encapsulate very important information.

Coverage that spans each point of clinical pharmacology:

  • simple rules
  • Autonomic medicinal drugs
  • Cardiovascular-renal medicines
  • medicinal drugs with very important activities on gentle muscle tissue
  • crucial frightened method medications
  • medicines used to regard anemias, clotting issues, hyperlipidemia, and irritation and gout
  • Endocrine medicines
  • Chemotherapeutic and immunologic medicines
  • Toxicology
  • distinctive topics (perinatal, geriatric, and dermatologic pharmacology)
  • Botanical and "food supplements," and over the counter drugs
  • Prescribing

Also during this edition:

  • Drug precis Tables finish so much chapters, delivering a concise precis of an important medicines
  • basic strategies when it comes to newly found receptors, receptor mechanisms, and drug transporters
  • Descriptions of significant new medicines, together with monoclonal antibodies

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Additional resources for Basic and Clinical Pharmacology 12/E

Sample text

Trastuzumab, an antibody that antagonizes growth factor receptor signaling (discussed earlier), is a useful therapeutic agent for breast cancer. Another example of this general approach is imatinib, a small molecule inhibitor of the cytoplasmic tyrosine kinase Abl, which is activated by growth factor signaling pathways.

The bound STATs are themselves phosphorylated by the JAKs, two STAT molecules dimerize (attaching to one another’s tyrosine phosphates), and finally the STAT/STAT dimer dissociates from the receptor and travels to the nucleus, where it regulates transcription of specific genes. Ligand- and Voltage-Gated Channels Many of the most useful drugs in clinical medicine act by mimicking or blocking the actions of endogenous ligands that regulate the flow of ions through plasma membrane channels. The natural ligands are acetylcholine, serotonin, GABA, and glutamate.

Each of their receptors transmits its signal across the plasma membrane by increasing transmembrane conductance of the 24 SECTION I Basic Principles Cytokine molecules + Cytokine R R JAK JAK P~Y R R Y~P JAK JAK P~Y STAT Y~P P~Y STAT Y~P STAT STAT FIGURE 2–8 Cytokine receptors, like receptor tyrosine kinases, have extracellular and intracellular domains and form dimers. However, after activation by an appropriate ligand, separate mobile protein tyrosine kinase molecules (JAK) are activated, resulting in phosphorylation of signal transducers and activation of transcription (STAT) molecules.

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