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Et al. (2004) Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development (Cambridge, England), 131 (16), 3931–3942. J. et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell, 128 (5), 947–959. (35) Seo, S. and Kume, T. (2006) Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Developmental Biology, 296 (2), 421–436.

Et al. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental Cell, 25 (4), 417–426. , and K¨uhl, M. (2006) The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart. Cardiovascular Research, 72 (2), 198–209. , Zhou, W. et al. (2007) β-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 104 (22), 9313–9318.

Arriving at this final configuration requires passage through what may be described as four major stages: specification of early cardiac progenitors and their coalescence into cardiogenic regions called heart fields; fusion of these cells at the midline to form the heart tube; cardiac looping and primitive chamber formation; and finally cardiac remodeling, including septation and valve formation. The first of these four stages of heart development is the specification and migration of cardiac progenitor cells from the mesoderm of the gastrula.

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