Download Biodegradable Polymers as Drug Delivery Systems (Drugs and by Mark Chasin PDF

By Mark Chasin

Reports the houses, synthesis, and formulations of a couple of good studied polymers more and more getting used in site-specific or systematic management of pharmaceutical brokers. for every of the polymers, discusses the historical past; chemistry and synthesis; the formula of microcapsules, solv

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Several of these products provide 30-40 days duration of action. A human contraceptive vaccine based on lactide polymers is currently being developed. The antigen is a 37 -amino-acid peptide of B-HCG conjugated to diphtheria toxoid. The antigen is administered wtih microencapsulated muramyl dipeptide as an adjuvant. 7 ANTIBODV CONe. 0 2 3 4 5 6 7 8 9 10 TIME/MONTHS FIGURE 11 IgG antibody levels in bovine milk following a single irrmunization with long-acting bacterial antigen microspheres. Lactidel Glycolide Polymers 29 a single injection of microspheres (Fig.

M. Anderson and S. W. ), Elsevier, New York, 1986, pp. 179-186. Ratcliffe, J. , Hunneyball, I. , Wilson~ C. , and Davis, s. , Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs, ~ Pharm. , 36, 431, 1984. , Howard, S. , Malanga, C. , Cuzzi, L. , Hogan, T. , Kandzari, S. , and Ma, J. , Kinetics of drug roelease froom polylactic acid-hydrocortisone microcapsules, J. , Benoit, J. , The formation and characterization of hydrocortisone-loaded poly«+/-)-lactide) microspheres, J.

Lewis, D. , and Tice, T. , Evaluation of a new thre'=-month injectable contraceptive microsphere system in primates (baboon), Contracept. Deliv. , 1, 79, 1980. Beck, L. , Pope, V. , Tice, T. , and Gilley, R. , Long-acting injectable microsphere formulation for the parenteral administration of levonorgestrei. Adv. , 1, 119, 1985. Lewis, D. , Meyers, W. , Dunn, R. , and Tice, T. , The use of in vitro release methods to guide the development of controlled release formulations, Proc. Int. Symp. Control.

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