By C. Stan Tsai
This booklet offers an built-in remedy of the constitution and serve as of nucleic acids, proteins, and glycans, together with thorough assurance of appropriate computational biochemistry.
The textual content starts with an advent to the biomacromolecules, through dialogue of equipment of isolation and purification, physiochemical and biochemical houses, and structural features. the subsequent part of the e-book bargains with series research, research of conformation utilizing spectroscopy, chemical synthesis, and computational ways. the subsequent chapters speak about biomolecular interactions, enzyme motion, gene transmission, sign transduction, and biomacromolecular informatics. the writer concludes with featuring the newest findings in genomics, proteomics, glycomics, and biomacromolecular evolution.
This textual content is a useful source for examine execs wishing to maneuver into genomics, proteomics, and glycomics examine. it's also beneficial for college students in biochemistry, molecular biology, bioengineering, biotechnology, and bioinformatics.
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Extra resources for Biomacromolecules. Intro to Structure, Function and Informatics
Glycoses contain several chiral centers at secondary hydroxyl carbons, resulting in numerous stereoisomers. The carbonyl functional group forms a cyclic hemiacetal or hemiketal with one of hydroxyl groups (normally C4 or C5) to yield a ﬁve-membered furanose ring or six-membered pyranose ring. When hemiacetals and hemiketals are formed, the carbon atom that carries the carbonyl function becomes a chiral carbon atom. Isomers of glycoses that differ only in their conﬁguration about this carbon atom (anomeric carbon) are called anomers, designated as α- or β-anomer.
S. (1998) Principles of Physical Biochemistry, Prentice Hall, Upper Saddle River, NJ. G. and Blackwell, J. (1973) Biopolymer, Academic Press, New York. Warshel, A. T. (1984) Quarterly Review of Biophysics, 17, 283–422. Whitford, D. (2005) Proteins: Structure and Function, John Wiley & Sons, Hoboken, NJ. , 2002; Voet and Voet, 2004; Garrett and Grisham, 2005), whose great range of physicochemical and biochemical characteristics are derived mainly from the varied properties of their constituent monomer molecules.
170 Note: Covalent radii for two atoms can be summed to give the interatomic distance. The van der Waals radii determine how closely molecules can pack. They are usually measured from the shortest distances that can exist between neighboring (and not covalently bonded) atoms in the crystalline state. 02 nm less than the sum of the van der Waals radii. 3 NONCOVALENT INTERACTIONS 5 projected bonds A—B and C—D when looking along the central bond in either direction. It is deﬁned as 0° if A—B and C—D are eclipsed (cis and coplanar), and the sign is positive if the far bond is rotated clockwise with respect to the near bond.
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