By Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi
Since its id through Sir Henry H. Dale a century in the past, histamine has develop into some of the most very important multifunctional biogenic amines within the box of biomedicine. The pharmacological results of histamine are mediated via 4 varieties of membrane histamine receptors; H1R, H2R, H3R and H4R, that are all heptahelical G-protein-coupled receptors. it's been identified to play the broadest spectrum of actions in numerous physiological and pathological stipulations together with telephone proliferation, differentiation, hematopoiesis, embryonic improvement, regeneration, wound therapeutic, aminergic neurotransmission and various mind features, secretion of pituitary hormones, law of gastrointestinal and circulatory services, cardiovascular procedure, in addition to inflammatory reactions, modulation of the immune reaction, endocrine functionality and homeostasis, and different vital parts.
This e-book is a compendium of the present country of verified and investigational literature on Histamine, its receptors and their Agonists and antagonists. It presents a entire review of histamine biology within the box of biochemistry, telephone biology, molecular biology, immunology, allergic reaction, neurobiology, pharmacology, microbiology and reproductive biology. the 1st part on Histamine biology and body structure leads into next sections on enzymology, pharmacology, rules of the immune method and mobilephone proliferation and position in allergic and different ailments together with acid peptic ailments, inflammatory illnesses, autoimmune and melanoma ailments, anxious approach, reproductive services and hematopoiesis. The compilation of chapters within the ebook provides the latest advances in histamine learn and bridges the fundamental and medical points of histamine biology.
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Extra info for Biomedical Aspects of Histamine: Current Perspectives
1993). One of the potential candidates for non-mast cell histamine-forming cells is macrophages (Kawaguchi-Nagata et al. 1985). Takamatsu et al. (1996) first demonstrated that bone marrow-derived macrophages can produce histamine in response to endotoxin. 7, in which the 74-kDa HDC was dominantly expressed (Hirasawa et al. 2001, Shiraishi et al. 2000). Accumulating evidence suggests that nascent histamine produced by macrophages plays critical roles in suppression of immune responses mainly by acting on the H2 receptor (Yokoyama et al.
2005). Since stimulation of histamine synthesis occurs upon IgE-mediated antigen induction, and this remains controversial if these two modes of FcεRI activation share a common signal transduction pathway. However, many recent studies have demonstrated the qualitative differences between both modes: such as monomeric IgE-induced Ca2+ influx is mediated by a distinct channel from that activated upon antigen stimulation (Tanaka et al. 2005), and protein kinase C β-II (PKCβII) plays a significant role in monomeric IgE-induced histamine synthesis in mast cells, but not upon antigen stimulation (Liu et al.
J Exp Med 196:229–235 Tsujikawa T, Uda K, Ihara T et al (1999) Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies. Cancer Lett 147:195–198 Watson F, Kiernan RS, Dimaline R (2002) GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium. Biochem Biophys Acta 1576:198–202 Yatsunami K, Ohtsu H, Tsuchikawa M et al (1994) Structure of the L hidtidine decarboxylase gene. J Biol Chem 269:1554–1559 Yokoyama M, Yokoyama A, Mori S et al (2004) Inducible histamine protects mice from P.
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