By G. Winkelmann
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Extra info for Biometals
2000). H2O2 also contributes to the formation of hydroxyl radicals (HOÁ), especially in the presence of metal ions (usually iron), through the Fenton or Haber–Weiss reactions (Mladenka et al. 2006). In addition, H2O2 can react with HOCl, to yield another highly reactive ROS, singlet oxygen (1O2; Costa et al. 2008; Miyamoto et al. 2007). Likewise ROS, the production of RNS is also highly increased in the event of inflammatory processes, and contributes to the antimicrobial activity. Inducible nitric oxide synthase (iNOS) transforms Á L-arginine into nitric oxide ( NO) and L-citrulline.
Thus, the use of a phosphate-free incubation media is recommended for evaluating the influence of metals on neutrophils’ oxidative burst. In addition, the use of different methods to detect reactive species is essential to avoid erroneous conclusions, as demonstrated in the present study. 5 lM) activate NADPH oxidase, mainly via PKC, leading to the formation of O2•-. Higher concentrations of zinc results on a rapid dismutation of O2•- to O2 and H2O2, which in turn is used by MPO to generate HOCl.
A review. Anal Chim Acta 649:8–23 Biometals (2010) 23:31–41 Freitas M, Porto G, Lima JL, Fernandes E (2009b) Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro. Talanta 78:1476–1483 Hampton MB, Kettle AJ, Winterbourn CC (1998) Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92:3007–3017 Hasegawa H, Suzuki K, Nakaji S, Sugawara K (2000) Effects of zinc on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity in vitro.
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