By Kevin Strange (auth.), Kevin Strange (eds.)
Molecular biology has pushed a strong reductionist, or “molecule-c- tric,” method of organic learn within the final 1/2 the twentieth century. purple- tionism is the try to clarify advanced phenomena by way of defining the sensible homes of the person elements of the process. Bloom (1) has talked about the post-genome sequencing period because the finish of “naïve reductionism. ” pink- tionist equipment will stay a necessary section of all organic learn efforts, yet “naïve reductionism,” the assumption that reductionism by myself may end up in a whole realizing of residing organisms, isn't tenable. Organisms are truly even more than the sum in their elements, and the habit of advanced physiological approaches can't be understood just by understanding how the components paintings in isolation. platforms biology has emerged within the wake of genome sequencing because the s- cessor to reductionism (2–5). The “systems” of structures biology are outlined over a large span of complexity starting from macromolecules that have interaction to hold out a selected activity to entire organisms. structures biology is integrative and seeks to appreciate and expect the habit or “emergent” houses of complicated, multicomponent organic strategies. A systems-level characteri- tion of a organic technique addresses the next 3 major questions: (1) What are the elements of the procedure (i. e.
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Extra info for C. elegans: Methods and Applications
6, 237–245. 42 Kent, W. J. and Zahler, A. M. (2000) Conservation, regulation, synteny, and introns 42. in a large-scale C. briggsae–C. elegans genomic alignment. Genome Res. 10, 1115– 1125. , Kent, W. , et al. (2004) Aligning multiple genomic 43. sequences with the threaded blockset aligner. Genome Res. 14, 708–715. WormBase: Data Mining 31 3 WormBase Methods for Data Mining and Comparative Genomics Todd W. Harris and Lincoln D. Stein Summary WormBase is a comprehensive repository for information on Caenorhabditis elegans and related nematodes.
Uploaded annotations are also included in images generated from the “Publication Quality Image” link. This option creates a scalable vector graphics image of the current genome span. Scalable vector graphics images can be edited in vector-based graphics applications, enlarged or compressed with no loss in quality, and submitted as high quality figures for publication. To publish preliminary data sets or remote annotations, users may make use of the distributed annotation system (DAS) (21). Using DAS, annotations are hosted on a remote server but displayed in the context of WormBase by a DAS client (in this case the Genome Browser).
Trends Parasitol. 20, 151–153. 31 Webb, C. , Shabalina, S. , Ogurtsov, A. , and Kondrashov, A. S. (2002) 31. Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae. Nucleic Acids Res. 30, 1233–1239. , Kent, W. , et al. (2003) Human-mouse alignments with 32. BLASTZ. Genome Res. 13, 103–107. , Mesirov, J. , and Lander, E. S. (2000) 33. Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res.
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