Download Cellular Bioenergetics: Role of Coupled Creatine Kinases by Valdur A. Saks, Renée Ventura-Clapier PDF

By Valdur A. Saks, Renée Ventura-Clapier

Most of the knowledge at the sensible position, constitution and molecular biology of creatine kinase is scattered in numerous thousands of guides. The editors of this quantity invited all authors who're so much energetic at this time in experimental study on creatine kinases to summarize their paintings and make the data simply to be had to a much wider medical viewers, specially to younger investigators who're getting into this box. because the sensible position of coupled creatine kinases is at once regarding the phenomenon of compartmentation and structural association of metabolic networks, we additionally invited specialists within the similar components to give a contribution to the quantity. just about all invited authors answered enthusiastically and the result of this collective paintings are offered right here.
For biochemists, biophysicists, physiologists, and clinical learn employees.

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Therefore, we decided to address several aspects of the heterogeneity question using intra-myocardial measurements ofNADH fluorescence (NADH/ NAD redox state) in conjunction with laser doppler techniques to estimate tissue perfusion. The goal was to evaluate regional gradients or patterns of response of the heart during ischemia [45]. 45 mm in diameter) were introduced various distances into the myocardium and used to measure regional changes in NADH redox state and perfusion compared to surface changes (obtained with 2 mm surface fiberoptic light guides), during 2 min periods of ischemia produced with a balloon occluder placed around the proximal left anterior descending coronary artery (LAD) (Fig.

Biochim Biophysi Acta, in press 1994 150. Osbakken M, Zhang D, Ivanics T, Rawson N, Friedman M: Bioenergetics of sodium transport in models of disease. Proc Mag Res Med Abstract, P364, vol. 2, 1993 151. Osbakken M, Ivanics T, Zhang D, Blum H: Glycolysis is necessary for sodium transport in cardiomyocytes. Proc Mag Res Med, Abstract P2209, vol. 2, 1992 152. Kondrashova MN, Doliba NM: Polarographic observation of substrate-level phosphorylation and its stimulation of acetylcholine. FEB Letter 243(2): 153-155, 1989 153.

Under stimulated conditions, glucose uptake and glycogen catabolism occur at similar rates, suggesting that lactate could arise from either or both substrates. Surprisingly, the specific activity of lactate was identical to that of glucose, indicating that all of the lactate production originated from glucose, despite the entry of glucosyl moieties from glycogen into the glycolytic pathway [8]. Thus even in the absence of identifiable barriers and the small size of vascular smooth muscle cells relative to diffusion, glycolytic intermediates arising from glucose did not mix with the pool of intermediates originating from glycogen.

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