Download Chemical biology in regenerative medicine : bridging stem by Charles C. Hong, Ada S. Ao, Jijun Hao PDF

By Charles C. Hong, Ada S. Ao, Jijun Hao

Chemical Biology in Regenerative drugs: Bridging Stem Cells and destiny Therapies

The box of regenerative medication has complex at a quick velocity and this complete precis of latest advancements is a well timed contribution to the sector as medical trials have started to evaluate the security and efficacy of cell-based therapies.

In Chemical Biology in Regenerative drugs, an overseas crew of specialists offers an outline of development in the direction of medical program within the parts of transplantation (allogenic and autologous), manipulation of area of interest surroundings and homing, and mobile reprogramming (trans-differentiation and de-differentiation). The booklet highlights the interdisciplinary techniques undertaken to solve present technical difficulties in regenerative drugs, with detailed awareness paid to small molecules and biomaterials engineering.

This quantity offers an important assessment of this rising know-how for researchers in educational, business and medical environments operating in regenerative drugs, chemical biology, biochemistry, cellphone biology, biomaterials and bioengineering. it truly is applicable for education scholars and novices to the sector, benefitting readers in broadening their wisdom and giving them insights to regenerative chemical biology, in addition to encouraging readers to enforce the major issues of their personal fields of analysis to enhance new technologies.

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Et al. (2004) Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development (Cambridge, England), 131 (16), 3931–3942. J. et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell, 128 (5), 947–959. (35) Seo, S. and Kume, T. (2006) Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Developmental Biology, 296 (2), 421–436.

Et al. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental Cell, 25 (4), 417–426. , and K¨uhl, M. (2006) The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart. Cardiovascular Research, 72 (2), 198–209. , Zhou, W. et al. (2007) β-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 104 (22), 9313–9318.

Arriving at this final configuration requires passage through what may be described as four major stages: specification of early cardiac progenitors and their coalescence into cardiogenic regions called heart fields; fusion of these cells at the midline to form the heart tube; cardiac looping and primitive chamber formation; and finally cardiac remodeling, including septation and valve formation. The first of these four stages of heart development is the specification and migration of cardiac progenitor cells from the mesoderm of the gastrula.

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