Download Colloid and interface science in pharmaceutical research and by Hiroyuki Ohshima, Kimiko Makino PDF

By Hiroyuki Ohshima, Kimiko Makino

Colloid and Interface technology in Pharmaceutical study and Development describes the function of colloid and floor chemistry within the pharmaceutical sciences. It provides a close account of colloid idea, and explains physicochemical homes of the colloidal-pharmaceutical structures, and the tools for his or her dimension.

The e-book begins with basics partially I, overlaying basic features of colloid and interface sciences as utilized to pharmaceutical sciences and therefore can be compatible for instructing. elements II and III deal with functions and measurements, and so they explains the appliance of those houses and their impression and use for the advance of recent medications.

  • Provides a transparent description of the basics of colloid and interface technological know-how suitable to drug learn and development
  • Explains the physicochemical/colloidal foundation of pharmaceutical science
  • Lists glossy experimental characterization concepts, presents analytical equations and factors on reading the experimental data
  • Describes the main complicated ideas, AFM (Atomic strength Microscopy), SFA (Surface strength equipment) in detail

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Extra info for Colloid and interface science in pharmaceutical research and development

Sample text

7 Liposomes and Vesicles in Pharmacy ............................................................... 8 Stabilisation of Liposomes by Incorporation of Block Copolymers ....................... 9 Nanoparticles, Drug Delivery and Drug Targetting .............................................. 10 The Reticuloendothelial System ....................................................................... 11 Influence of Particle Characteristics ................................................................

Several criteria for effective steric stabilisation can be defined: (i) The particles or droplets should be completely covered by the surfactant or polymer (the amount should correspond to the plateau value). Any bare patches may cause flocculation either by van der Waals attraction between the bare patches or by bridging flocculation, in which a polymer molecule will become simultaneously adsorbed on two or more particles or droplets. (ii) The polymer should be strongly ‘anchored’ to the particles or droplets surface, to prevent any displacement during particle approach – this is particularly important for concentrated suspensions or emulsions.

Both lecithin and cholesterol can exchange with membranes of red blood cells. The susceptibility of liposomal phospholipid and phospholipase is strongly dependent on liposome size and type. Generally MLVs (Multilayer Vesicle) are most stable and SUVs (Single layer vesicle) are least stable. Liposomes prepared with higher chain length phospholipids are more stable in buffer and in plasma. Cholesterol and sphingomyelin are very effective in reducing instability. As we will see later, incorporation of block copolymers such as poloxamers can enhance the stability of liposomes.

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