Download DNA Methylation: Biochemistry and Biological Significance by Aharon Razin, Howard Cedar, Arthur D. Riggs (auth.), Aharon PDF

By Aharon Razin, Howard Cedar, Arthur D. Riggs (auth.), Aharon Razin, Howard Cedar, Arthur D. Riggs (eds.)

During the earlier few a long time we now have witnessed an period of outstanding development within the box of molecular biology. In 1950 little or no was once recognized of the chemical structure of organic structures, the way within which info was once trans­ mitted from one organism to a different, or the level to which the chemical foundation of existence is unified. the image this present day is dramatically varied. we've got a virtually bewildering number of info detailing many various elements of lifestyles on the molecular point. those nice advances have introduced with them a few breath-taking insights into the molecular mechanisms utilized by nature for rep­ licating, allotting and enhancing organic details. we have now realized greatly in regards to the chemical and actual nature of the macromolecular nucleic acids and proteins, and the way within which carbohydrates, lipids and smaller molecules interact to supply the molecular atmosphere of residing sys­ tems. it would be stated that those few many years have changed a close to vacuum of data with a truly huge surplus. it truly is within the context of this flood of data that this sequence of monographs on molecular biology has been prepared. the belief is to collect in a single position, among the covers of 1 ebook, a concise review of the country of the topic in a well-defined box. this can allow the reader to get a feeling of ancient perspective-what is understood concerning the box today-and an outline of the frontiers of study the place our wisdom is expanding steadily.

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Extra info for DNA Methylation: Biochemistry and Biological Significance

Sample text

Type II enzymes are structurally and mechanistically simpler. Typically, the restriction endonuclease is a dimer of a single type of subunit (although a few appear to be monomers), requires Mg2+ for activity, and cleaves within the site or only a few base pairs away. The modification methylase is a separate protein, usually a monomer, and catalyzes transfer of a methyl group from AdoMet to one of the bases (A or C) on each straind of the site. As a possible exception, certain asymmetric sites may be methylated on only one strand.

EcoPl was similar, but the smaller subunit had a mol wt of approximately 75,000. The size of the subunits and of the genes is consistent, with the larger one being the res gene product and the smaller one being the product of the mod gene. The subunit functions of EcoPl and EcoP15 were determined by experiments using an antibody against EcoP15 (Hadi et al. 1983). Purified EcoP15 and a crude extract from a res- mod+ deletion mutant of EcoP15 were electrophoresed in the presence of sodium dodecyl sulfate, and the gel was then reacted with the EcoP15 antibody.

Glover SW: Functional analysis of host-specificity mutants in Escherichia coli. Genet Res 1970;15:237-250. Gough JA, Murray, NE: Sequence diversity among related genes for recognition of specific targets in DNA molecules. J Mol Bioi 1983;166:1-19. Haberman A: The bacteriophage PI restriction endonuclease. J Mol Bioi 1974; 89:545-563. Haberman A, Heywood J, Meselson M: DNA modification methylase activity of Escherichia coli restriction endonucleases K and P. Proc Nat! Acad Sci USA 1972; 69:3138-3141.

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