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Extra info for Drug Delivery: Fundamentals and Applications
Drug release results from the exchange of bound drug ions with ions commonly available in body fluids (such as Na+, K+, or Cl−). However, in many cases, a combination of factors is involved, and this can be exploited to give a range of release profiles. Mechanisms of drug release will be discussed further in the following sections. 2 IMMEDIATE RELEASE DELIVERY SYSTEMS As mentioned earlier, the primary role of IR dosage forms is to give a rapid onset of drug action and to achieve a high plasma concentration quickly.
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Wright. 2012. Historical overview of long acting injections and implants. In Long Acting Injections and Implants, eds. J. Wright and D. Burgess, pp. 11–24. New York: Springer. Y. Wang, T. Shimizu et al. 2007. PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner. J Control Release 122:349–355. H. S. Lee et al. 1997. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388:860–862. H. Moeller, M. van de Weert et al. 2006. Preparing and evaluating delivery systems for proteins.
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