Download Dynamic Combinatorial Chemistry: In Drug Discovery, by Benjamin L. Miller PDF

By Benjamin L. Miller

Effective thoughts for utilizing Dynamic Combinatorial Chemistry

In a comparatively brief interval, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a number of remoted labs to a huge conceptual framework with functions to a very good diversity of difficulties in molecular attractiveness, lead compound identity, catalyst layout, nanotechnology, polymer technology, and others. Bringing jointly a bunch of revered specialists, this review explains how chemists can practice DCC and fragment-based library ways to lead iteration for drug discovery and molecular attractiveness in bioorganic chemistry and fabrics science.

Chapters cover:

  • Basic theory

  • Approaches to binding in proteins and nucleic acids

  • Molecular recognition

  • Self-sorting

  • Catalyst discovery

  • Materials discovery

  • Analytical chemistry challenges

A entire, single-source reference approximately DCC tools and functions together with elements of fragment-based drug discovery, this can be a center reference that might spark the improvement of latest recommendations and techniques for chemists construction constitution libraries and designing compounds and materials.

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Extra resources for Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science

Example text

2005, 127, 13666–13671. 35. Berkovich-Berger; Lemcoff, N. G. Facile acetal dynamic combinatorial library. Chem. Commun. 2008, 1686–1688. 36. Brady, P. ; Sanders, J. K. M. Thermodynamically controlled cyclisation and interconversion of oligocholates: Metal ion templated ‘living’ macrolactonisation. J. Chem. Soc. Perkin I 1997, 3237–3253. 37. Rowan, S. ; Hamilton, D. ; Brady, P. ; Sanders, J. K. M. Automated recognition, sorting, and covalent self-assembly by predisposed building blocks in a mixture.

Probing selectivity in recognition-mediated dynamic covalent processes. Org. Lett. 2006, 8, 3651–3654. 54. Eliseev, A. ; Nelen, M. I. Use of molecular recognition to drive chemical evolution. 1. Controlling the composition of an equilibrating mixture of simple arginine receptors. J. Am. Chem. Soc. 1997, 119, 1147–1148. 55. Ingerman, L. ; Waters, M. L. Photoswitchable dynamic combinatorial libraries: Coupling azobenzene photoisomerization with hydrazone exchange. J. Org. Chem. 2009, 74, 111–117.

A. 2002, 99, 3382–3387. 82. Nitschke, J. -M. Self-organization by selection: Generation of a metallosupramolecular grid architecture by selection of components in a dynamic library of ligands. Proc. Natl. Acad. Sci. A. 2003, 100, 11970–11974. 83. Corbett, P. ; Sanders, J. K. M. Correlation between host–guest binding and host amplification in simulated dynamic combinatorial libraries. Chem. Eur. J. 2004, 10, 3139–3143. 84. Corbett, P. ; Sanders, J. K. ; Otto, S. Competition between receptors in dynamic combinatorial libraries: Amplification of the fittest?

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