By Kumar Gadamasetti
Supplying tips for chemists and different scientists coming into pharmaceutical discovery and development, this up to the moment reference provides contributions from a global workforce of approximately 50 well known researchers―offering a fantastic grounding in man made and actual natural chemistry, and clarifying the jobs of varied specialties within the improvement of latest medicines.
Featuring over a thousand references, tables, and illustrations, Process Chemistry within the Pharmaceutical Industry is certain to discover its option to the bookshelves of natural, actual, analytical, method, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate scholars in those disciplines.
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Delivering assistance for chemists and different scientists getting into pharmaceutical discovery and improvement, this up to date reference provides contributions from a global staff of approximately 50 well known researchers―offering an exceptional grounding in artificial and actual natural chemistry, and clarifying the jobs of varied specialties within the improvement of recent medicinal drugs.
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Extra resources for Process Chemistry in the Pharmaceutical Industry
The difficult, yet highly processable synthesis of Vitamin D involving photolysis (chapter 5), by the Hoffmann-La Roche Process group and the enantioselective route to azetidinones comprising an aldol reaction and a novel fluoride catalyzed cyclization (Chapter 13; Schering-Plough Research Institute) are noteworthy.
N. J. Org. Chem. -J. Tetrahedron Lett. 1993, 34, 2259. ; Nicaise, O. Synlett 1993, 359. ; Koga, K. Tetrahedron Lett. ; Tomioka, K. Tetrahedron 1994, 50, 4429. ; Solladie, G. Tetrahedron Lett. R. J. Org. Chem. W. Chem. Ber. -P. Tetrahedron Lett. ; Narayana, C. Synth. Commun. ; Singaram, B. Tetrahedron Lett. -M. O. Synth. Commun. 1996, 26, 2009. P. J. Chem. Soc. Chem. Commun. -U. Angew. Chem. Int. Ed. Engl. E. J. Am. Chem. Soc. S. ; Cosford, N. ; Shiota, T. J. Chem. Soc. Chem. Commun. 1994, 725. B.
An elegant solution to the problem was generated by the finding that water wet n-butanol solutions of the 70:30/SR:RR mixture, as obtained after extracting the DBTA from the resolution mother liquors, could be racemized utilizing a strong cation exchange resin Dowex XFS 43279 (H+) was particularly effective. This operation was conducted in a batch fashion using a 2000 gallon jacketed glass-lined vessel equipped with a filter in the bottom valve for drawing off liquids. After loading the SR/RR mixture, the n-butanol was sucked away, the loaded resin washed successively with one bed volume of n-butanol, followed by water, aq 5% sulfuric acid and water.
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