By Günter Mayer
With vast insurance of synthesis suggestions and purposes, this article describes chemical biology thoughts that have received major impetus over the past 5 years. It specializes in the equipment for acquiring transformed and local nucleic acids, and their organic purposes. themes lined comprise: chemical synthesis of converted RNAexpansion of the genetic alphabet in nucleic acids by means of developing new base pairschemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with transformed nucleotidesnucleic-acid-templated chemistrychemical biology of peptide nucleic acids (PNA)the interactions of small molecules with DNA and RNAthe architectural modules of folded RNAsgenesis and organic functions of locked nucleic acid (LNA)small non-coding RNA in bacteriamicroRNA-guided gene silencingnucleic acids established therapiesinnate immune attractiveness of nucleic acidlight-responsive nucleic acids for the spatiotemporal keep an eye on of organic processesDNA methylationframeworks for programming RNA devicesRNA as a catalyst: The Diels-Alderase-Ribozymeevolving an figuring out of RNA functionality through in vitro approachesthe chemical biology of aptamers: synthesis and applicationsnucleic acids as detection toolsbacterial riboswitch discovery and analysisThe Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their organic purposes for bioorganic chemists, chemical biologists, medicinal chemists, cellphone biologists, and molecular biologists.
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Additional resources for The Chemical Biology of Nucleic Acids
This strategy generates only the desired 20 -O-alkylated isomers of precious modified compounds and is required for modifications that are not stable under the conditions for installation of the TOM protecting group. The majority of reported syntheses followed one of these two general routes. In principle, alternative synthetic approaches are conceivable and the exact sequence of synthesis steps is largely depending on the chemical stability of the targeted nucleobase modification. 3 (a) General routes for the synthesis of nucleobase-modified 20 -O-TOM-protected phosphoramidites.
A combination of the convertible nucleoside approach and thiol-specific RNA labeling together with enzymatic ligation was applied for engineering of pre-mRNA and snRNA constructs [130,131]. In these studies, a site-specifically attached hydroxyl radical probe (Fe-BABE) was used to investigate the architecture of early spliceosomal complexes. A recent addition to the repertoire of available methods for covalent ligation of RNA fragments comes from the in vitro selection of deoxyribozymes. Silverman and co-workers reported practically useful DNA catalysts for the ligation of a 50 -triphosphate RNA donor substrate to the 30 -hydroxyl group of a second RNA fragment [132,133].
Bioorg. Med. Chem. Lett. 12, 3345–3347. 47. A. (2006) Improved synthesis of 20 -amino-20 -deoxyguanosine and its phosphoramidite. Bioorg. Med. Chem. 14, 705–713. 48. , Polacek, N. (2008) The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chem. Biol. 15, 485–492. 49. A. (2008) The 20 -hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction. Biochemistry 47, 7684–7694. 50. , Micura, R.
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