Download Veterinary Toxicology by Joseph D. Roder, D.V.M., Ph.D., D.A.B.V.T. (Auth.) PDF

By Joseph D. Roder, D.V.M., Ph.D., D.A.B.V.T. (Auth.)

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Primary Photosensitivity GENERAL • Caused by • members of the Umbelliferae family (celery, parsnip, parsley) • St. John’s wort (Hypericum perforatum) • buckwheat (Fagopyrum esculentum) • perennial rye grass (Lolium perenne) PATHOPHYSIOLOGY The foregoing plants contain pigments called furocoumarins that can cause photodermatitis directly without metabolic activation. Secondary Photosensitivity GENERAL • Hepatogenous, bighead in sheep • Produced by many plants and toxins that act on the liver • Hepatic damage precedes dermal signs PATHOPHYSIOLOGY • Sequela of liver damage • decreased hepatic function • decreased bilirubin conjugation • A primary function of the liver of herbivores is to degrade and remove the photodynamic pigments of plants, especially chlorophyll.

1997;39:296–298. 3 Pathophysiology of Selected Mechanisms ␥-Aminobutyric Acid–Mediated Chloride Channel • ␥-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system of vertebrates (Figure 3–1). • The GABA-mediated chloride channel is the site of action of many drugs and toxins. • Insect GABA receptors are present in the periphery at the neuromuscular junction. • Mammalian receptors are protected by the blood-brain barrier. • Ivermectin acts as an agonist of GABA receptors.

A review of Heinz-body anemia in the dog induced by toxins. Vet Hum Toxicol. 1993;l35:158–161. Rumbeiha WK, Lin YS, Oehme FW. Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats. Am J Vet Res. 1995;56:1529–1533. Wilkie DA, Kirby R. Methemoglobinemia associated with dermal application of benzocaine cream in a cat. J Am Vet Med Assoc. 1988; 192:85–86. Yeruham I, Shlosberg A, Hanji V, et al. Nitrate toxicosis in beef and dairy cattle herds due to contamination of drinking water and whey.

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